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Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line
A series of organometallic half-sandwich dichloridoruthenium(II) complexes of the general formula [Ru(η (6)-p-cym)(naza)Cl(2)] (1–8; p-cym = p-cymene; naza = 7-azaindole or its derivatives) was synthesised and fully characterized by elemental analysis, mass spectrometry, and infrared and multinuclea...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659567/ https://www.ncbi.nlm.nih.gov/pubmed/26606245 http://dx.doi.org/10.1371/journal.pone.0143871 |
Sumario: | A series of organometallic half-sandwich dichloridoruthenium(II) complexes of the general formula [Ru(η (6)-p-cym)(naza)Cl(2)] (1–8; p-cym = p-cymene; naza = 7-azaindole or its derivatives) was synthesised and fully characterized by elemental analysis, mass spectrometry, and infrared and multinuclear NMR spectroscopy. A single-crystal X-ray structural analysis of [Ru(η (6)-p-cym)(2Me4Claza)Cl(2)] (6) revealed a typical piano-stool geometry with an N7-coordination mode of 2-methyl-4-chloro-7-azaindole (2Me4Claza). The complexes have been found to be inactive against human ovarian cancer cell line A2780 up to the highest applied concentration (IC(50) > 50.0 μM). An inactivity of the complexes is caused by their instability in water-containing solvents connected with a release of the naza N-donor ligand, as proved by the detailed (1)H NMR, mass spectrometry and fluorescence experiments. |
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