Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MCL1. Furthermore, ER (endoplasmic reticulum) stress...

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Detalles Bibliográficos
Autores principales: Paiva, Cody, Godbersen, J. Claire, Soderquist, Ryan S., Rowland, Taylor, Kilmarx, Sumner, Spurgeon, Stephen E., Brown, Jennifer R., Srinivasa, Sreesha P., Danilov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659573/
https://www.ncbi.nlm.nih.gov/pubmed/26606677
http://dx.doi.org/10.1371/journal.pone.0143685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659573/
https://www.ncbi.nlm.nih.gov/pubmed/26606677
http://dx.doi.org/10.1371/journal.pone.0143685

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