Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

Mineralocorticoid receptor (MR) inactivation in mice results in early postnatal lethality. Therefore we generated mice in which MR expression can be silenced during adulthood by administration of doxycycline (Dox). Using a lentiviral approach, we obtained two lines of transgenic mice harboring a con...

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Detalles Bibliográficos
Autores principales: Montes-Cobos, Elena, Li, Xiao, Fischer, Henrike J., Sasse, André, Kügler, Sebastian, Didié, Michael, Toischer, Karl, Fassnacht, Martin, Dressel, Ralf, Reichardt, Holger M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659617/
https://www.ncbi.nlm.nih.gov/pubmed/26605921
http://dx.doi.org/10.1371/journal.pone.0143954

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