Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction

GPCRs catalyze GDP/GTP exchange in the α-subunit of heterotrimeric G proteins (Gαßγ) through displacement of the Gα C-terminal α5 helix, which directly connects the interface of the active receptor (R*) to the nucleotide binding pocket of G. Hydrogen–deuterium exchange mass spectrometry and kinetic...

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Detalles Bibliográficos
Autores principales: Rose, Alexander S., Zachariae, Ulrich, Grubmüller, Helmut, Hofmann, Klaus Peter, Scheerer, Patrick, Hildebrand, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659624/
https://www.ncbi.nlm.nih.gov/pubmed/26606751
http://dx.doi.org/10.1371/journal.pone.0143399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659624/
https://www.ncbi.nlm.nih.gov/pubmed/26606751
http://dx.doi.org/10.1371/journal.pone.0143399

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