Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persi...

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Autores principales: Kinloch-de Loes, Sabine, Dorrell, Lucy, Yang, Hongbing, Hardy, Gareth A. D., Yerly, Sabine, Cellerai, Cristina, Vandekerckhove, Linos, De Spielgelaere, Ward, Malatinkova, Eva, Wee Lee Koh, Willie, Johnson, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659693/
https://www.ncbi.nlm.nih.gov/pubmed/26613092
http://dx.doi.org/10.1093/ofid/ofv144
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author Kinloch-de Loes, Sabine
Dorrell, Lucy
Yang, Hongbing
Hardy, Gareth A. D.
Yerly, Sabine
Cellerai, Cristina
Vandekerckhove, Linos
De Spielgelaere, Ward
Malatinkova, Eva
Wee Lee Koh, Willie
Johnson, Margaret A.
author_facet Kinloch-de Loes, Sabine
Dorrell, Lucy
Yang, Hongbing
Hardy, Gareth A. D.
Yerly, Sabine
Cellerai, Cristina
Vandekerckhove, Linos
De Spielgelaere, Ward
Malatinkova, Eva
Wee Lee Koh, Willie
Johnson, Margaret A.
author_sort Kinloch-de Loes, Sabine
collection PubMed
description Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.
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spelling pubmed-46596932015-11-26 Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses Kinloch-de Loes, Sabine Dorrell, Lucy Yang, Hongbing Hardy, Gareth A. D. Yerly, Sabine Cellerai, Cristina Vandekerckhove, Linos De Spielgelaere, Ward Malatinkova, Eva Wee Lee Koh, Willie Johnson, Margaret A. Open Forum Infect Dis Brief Reports Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome. Oxford University Press 2015-11-23 /pmc/articles/PMC4659693/ /pubmed/26613092 http://dx.doi.org/10.1093/ofid/ofv144 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Kinloch-de Loes, Sabine
Dorrell, Lucy
Yang, Hongbing
Hardy, Gareth A. D.
Yerly, Sabine
Cellerai, Cristina
Vandekerckhove, Linos
De Spielgelaere, Ward
Malatinkova, Eva
Wee Lee Koh, Willie
Johnson, Margaret A.
Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses
title Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses
title_full Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses
title_fullStr Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses
title_full_unstemmed Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses
title_short Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses
title_sort aviremia 10 years postdiscontinuation of antiretroviral therapy initiated during primary human immunodeficiency virus-1 infection and association with gag-specific t-cell responses
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659693/
https://www.ncbi.nlm.nih.gov/pubmed/26613092
http://dx.doi.org/10.1093/ofid/ofv144
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