Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion

This data contains insights into the upregulation of the ER-Golgi-soluble N-ethylmaleimide-sensitive factor-attachment protein receptors (ER–Golgi SNAREs) syntaxin 5 (Syx5) by ER stress and the downregulation of Syx5 by apoptosis induction. Use of the protein synthesis inhibitor verified the de novo...

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Detalles Bibliográficos
Autores principales: Suga, Kei, Saito, Ayako, Akagawa, Kimio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659803/
https://www.ncbi.nlm.nih.gov/pubmed/26693512
http://dx.doi.org/10.1016/j.dib.2015.10.025
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author Suga, Kei
Saito, Ayako
Akagawa, Kimio
author_facet Suga, Kei
Saito, Ayako
Akagawa, Kimio
author_sort Suga, Kei
collection PubMed
description This data contains insights into the upregulation of the ER-Golgi-soluble N-ethylmaleimide-sensitive factor-attachment protein receptors (ER–Golgi SNAREs) syntaxin 5 (Syx5) by ER stress and the downregulation of Syx5 by apoptosis induction. Use of the protein synthesis inhibitor verified the de novo synthesis of Syx5 under ER stress in NG108-15 cells. We also provide validation data for the increase of Syx5 expression caused by ER stress using different chemical compound and overexpression analysis. Interpretation of our data and further extensive insights into the role of Syx5 in βAPP processing under ER stress can be found in Suga et al. (2015)[1].
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spelling pubmed-46598032015-12-21 Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion Suga, Kei Saito, Ayako Akagawa, Kimio Data Brief Data Article This data contains insights into the upregulation of the ER-Golgi-soluble N-ethylmaleimide-sensitive factor-attachment protein receptors (ER–Golgi SNAREs) syntaxin 5 (Syx5) by ER stress and the downregulation of Syx5 by apoptosis induction. Use of the protein synthesis inhibitor verified the de novo synthesis of Syx5 under ER stress in NG108-15 cells. We also provide validation data for the increase of Syx5 expression caused by ER stress using different chemical compound and overexpression analysis. Interpretation of our data and further extensive insights into the role of Syx5 in βAPP processing under ER stress can be found in Suga et al. (2015)[1]. Elsevier 2015-11-07 /pmc/articles/PMC4659803/ /pubmed/26693512 http://dx.doi.org/10.1016/j.dib.2015.10.025 Text en © 2015 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Suga, Kei
Saito, Ayako
Akagawa, Kimio
Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
title Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
title_full Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
title_fullStr Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
title_full_unstemmed Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
title_short Data supporting ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
title_sort data supporting er stress response in ng108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659803/
https://www.ncbi.nlm.nih.gov/pubmed/26693512
http://dx.doi.org/10.1016/j.dib.2015.10.025
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