Semaphorin 3A: A Potential Target for Low Back Pain

Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found to correlate with disease activity and histolo...

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Detalles Bibliográficos
Autores principales: Yin, Pengbin, Lv, Houchen, Zhang, Lihai, Zhang, Licheng, Tang, Peifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659908/
https://www.ncbi.nlm.nih.gov/pubmed/26635602
http://dx.doi.org/10.3389/fnagi.2015.00216
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author Yin, Pengbin
Lv, Houchen
Zhang, Lihai
Zhang, Licheng
Tang, Peifu
author_facet Yin, Pengbin
Lv, Houchen
Zhang, Lihai
Zhang, Licheng
Tang, Peifu
author_sort Yin, Pengbin
collection PubMed
description Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found to correlate with disease activity and histological features in some skeletal disorders. Based on its effects on innervation and vascularization, as well as enzyme secretion, we presume that semaphorin 3A may act as a potential target for low back pain.
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spelling pubmed-46599082015-12-03 Semaphorin 3A: A Potential Target for Low Back Pain Yin, Pengbin Lv, Houchen Zhang, Lihai Zhang, Licheng Tang, Peifu Front Aging Neurosci Neuroscience Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found to correlate with disease activity and histological features in some skeletal disorders. Based on its effects on innervation and vascularization, as well as enzyme secretion, we presume that semaphorin 3A may act as a potential target for low back pain. Frontiers Media S.A. 2015-11-26 /pmc/articles/PMC4659908/ /pubmed/26635602 http://dx.doi.org/10.3389/fnagi.2015.00216 Text en Copyright © 2015 Yin, Lv, Zhang, Zhang and Tang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yin, Pengbin
Lv, Houchen
Zhang, Lihai
Zhang, Licheng
Tang, Peifu
Semaphorin 3A: A Potential Target for Low Back Pain
title Semaphorin 3A: A Potential Target for Low Back Pain
title_full Semaphorin 3A: A Potential Target for Low Back Pain
title_fullStr Semaphorin 3A: A Potential Target for Low Back Pain
title_full_unstemmed Semaphorin 3A: A Potential Target for Low Back Pain
title_short Semaphorin 3A: A Potential Target for Low Back Pain
title_sort semaphorin 3a: a potential target for low back pain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659908/
https://www.ncbi.nlm.nih.gov/pubmed/26635602
http://dx.doi.org/10.3389/fnagi.2015.00216
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AT zhanglihai semaphorin3aapotentialtargetforlowbackpain
AT zhanglicheng semaphorin3aapotentialtargetforlowbackpain
AT tangpeifu semaphorin3aapotentialtargetforlowbackpain

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