Cargando…
Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?
Eukaryotic initiation factor eIF2 is a key component of the ternary complex whose role is to deliver initiator tRNA into the ribosome. A variety of stimuli, both physiologic and pathophysiologic activate eIF2 kinases that phosphorylate the α subunit of eIF2, preventing it from forming the ternary co...
Autor principal: | Holcik, Martin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659918/ https://www.ncbi.nlm.nih.gov/pubmed/26636041 http://dx.doi.org/10.3389/fonc.2015.00264 |
Ejemplares similares
-
The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy
por: Herrero, Melisa, et al.
Publicado: (2021) -
IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress
por: Thakor, Nehal, et al.
Publicado: (2012) -
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
por: Cnop, Miriam, et al.
Publicado: (2017) -
Searching for the Achilles Heel of FOXP3
por: Lozano, Teresa, et al.
Publicado: (2013) -
Could radiation exposure be the Achilles’ heel of distal transradial artery access?
por: Apostolos, Anastasios, et al.
Publicado: (2022)