Cargando…
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
Antigen receptor signalling activates the canonical NF-κB pathway via the CARD11/BCL10/MALT1 (CBM) signalosome involving key, yet ill-defined roles for linear ubiquitination. The paracaspase MALT1 cleaves and removes negative checkpoint proteins, amplifying lymphocyte responses in NF-κB activation a...
Autores principales: | Klein, Theo, Fung, Shan-Yu, Renner, Florian, Blank, Michael A., Dufour, Antoine, Kang, Sohyeong, Bolger-Munro, Madison, Scurll, Joshua M., Priatel, John J., Schweigler, Patrick, Melkko, Samu, Gold, Michael R., Viner, Rosa I., Régnier, Catherine H., Turvey, Stuart E., Overall, Christopher M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659944/ https://www.ncbi.nlm.nih.gov/pubmed/26525107 http://dx.doi.org/10.1038/ncomms9777 |
Ejemplares similares
-
The Paracaspase MALT1 in Cancer
por: Gomez Solsona, Beatriz, et al.
Publicado: (2022) -
Mechanism and specificity of the human paracaspase MALT1
por: Hachmann, Janna, et al.
Publicado: (2012) -
Immunodeficiency, auto-inflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
por: Boisson, Bertrand, et al.
Publicado: (2012) -
Masking MALT1: the paracaspase's potential for cancer therapy
por: Vucic, Domagoj, et al.
Publicado: (2009) -
Backbone Assignment of the MALT1 Paracaspase by Solution NMR
por: Unnerståle, Sofia, et al.
Publicado: (2016)