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Transient misfolding dominates multidomain protein folding

Neighbouring domains of multidomain proteins with homologous tandem repeats have divergent sequences, probably as a result of evolutionary pressure to avoid misfolding and aggregation, particularly at the high cellular protein concentrations. Here we combine microfluidic-mixing single-molecule kinet...

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Detalles Bibliográficos
Autores principales:	Borgia, Alessandro, Kemplen, Katherine R., Borgia, Madeleine B., Soranno, Andrea, Shammas, Sarah, Wunderlich, Bengt, Nettels, Daniel, Best, Robert B., Clarke, Jane, Schuler, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660218/ https://www.ncbi.nlm.nih.gov/pubmed/26572969 http://dx.doi.org/10.1038/ncomms9861

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