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Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many mal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660377/ https://www.ncbi.nlm.nih.gov/pubmed/26693400 http://dx.doi.org/10.1016/j.nicl.2015.10.017 |
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author | Blackmon, Karen Ben-Avi, Emma Wang, Xiuyuan Pardoe, Heath R. Di Martino, Adriana Halgren, Eric Devinsky, Orrin Thesen, Thomas Kuzniecky, Ruben |
author_facet | Blackmon, Karen Ben-Avi, Emma Wang, Xiuyuan Pardoe, Heath R. Di Martino, Adriana Halgren, Eric Devinsky, Orrin Thesen, Thomas Kuzniecky, Ruben |
author_sort | Blackmon, Karen |
collection | PubMed |
description | Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly. |
format | Online Article Text |
id | pubmed-4660377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-46603772015-12-21 Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder Blackmon, Karen Ben-Avi, Emma Wang, Xiuyuan Pardoe, Heath R. Di Martino, Adriana Halgren, Eric Devinsky, Orrin Thesen, Thomas Kuzniecky, Ruben Neuroimage Clin Regular Article Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly. Elsevier 2015-10-31 /pmc/articles/PMC4660377/ /pubmed/26693400 http://dx.doi.org/10.1016/j.nicl.2015.10.017 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Blackmon, Karen Ben-Avi, Emma Wang, Xiuyuan Pardoe, Heath R. Di Martino, Adriana Halgren, Eric Devinsky, Orrin Thesen, Thomas Kuzniecky, Ruben Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
title | Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
title_full | Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
title_fullStr | Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
title_full_unstemmed | Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
title_short | Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
title_sort | periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660377/ https://www.ncbi.nlm.nih.gov/pubmed/26693400 http://dx.doi.org/10.1016/j.nicl.2015.10.017 |
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