Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

Acetaminophen overdose is the leading cause of acute liver failure. One dose of 10–15 g causes severe liver damage in humans, whereas repeated exposure to acetaminophen in humans and animal models results in autoprotection. Insight of this process is limited to select proteins implicated in acetamin...

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Detalles Bibliográficos
Autores principales: Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., Starkey Lewis, P., Vasieva, O., Prats, N., Brillant, N., Auli, M., Bayliss, M., Webb, S., Rees, J. A., Kitteringham, N. R., Goldring, C. E., Park, B. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660393/
https://www.ncbi.nlm.nih.gov/pubmed/26607827
http://dx.doi.org/10.1038/srep16423

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