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Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study

BACKGROUND: Positron emission tomography (PET) images with amyloid tracers show normal uptake in healthy white matter, which suggests that amyloid tracers are potentially useful for studying such white matter diseases as multiple sclerosis (MS). METHODS: Twelve patients diagnosed with MS (5 with RRM...

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Autores principales: Matías-Guiu, Jordi A., Cabrera-Martín, María Nieves, Matías-Guiu, Jorge, Oreja-Guevara, Celia, Riola-Parada, Cristina, Moreno-Ramos, Teresa, Arrazola, Juan, Carreras, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660647/
https://www.ncbi.nlm.nih.gov/pubmed/26607782
http://dx.doi.org/10.1186/s12883-015-0502-2
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author Matías-Guiu, Jordi A.
Cabrera-Martín, María Nieves
Matías-Guiu, Jorge
Oreja-Guevara, Celia
Riola-Parada, Cristina
Moreno-Ramos, Teresa
Arrazola, Juan
Carreras, José Luis
author_facet Matías-Guiu, Jordi A.
Cabrera-Martín, María Nieves
Matías-Guiu, Jorge
Oreja-Guevara, Celia
Riola-Parada, Cristina
Moreno-Ramos, Teresa
Arrazola, Juan
Carreras, José Luis
author_sort Matías-Guiu, Jordi A.
collection PubMed
description BACKGROUND: Positron emission tomography (PET) images with amyloid tracers show normal uptake in healthy white matter, which suggests that amyloid tracers are potentially useful for studying such white matter diseases as multiple sclerosis (MS). METHODS: Twelve patients diagnosed with MS (5 with RRMS, 5 with SPMS, and 2 with PPMS) and 3 healthy controls underwent studies with MRI and (18)F-florbetaben-PET imaging. Images were preprocessed using Statistical Parametric Mapping software. We analysed (18)F-florbetaben uptake in demyelinating plaques (appearing as hyperintense lesions in FLAIR sequences), in normal-appearing white matter, and in grey matter. RESULTS: Mean standardized uptake value relative to cerebellum was higher in normally appearing white matter (NAWM) (1.51 ± 0.12) than in damaged white matter (DWM) (1.24 ± 0.12; P = .002). Mean percentage of change between NAWM and DWM was −17.56 % ± 6.22 %. This percentage of change correlated negatively with EDSS scores (r = −0.61, p < .05) and with age (r = −0.83, p < 0.01). Progressive forms of MS showed a more pronounced reduction of the uptake in DWM in comparison to relapsing-remitting form. CONCLUSIONS: Uptake of (18)F-florbetaben in damaged white matter is lower than that occurring in normally-appearing white matter. These findings indicate that amyloid tracers may be useful in studies of MS, although further research is needed to evaluate the utility of amyloid-PET in monitoring MS progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-015-0502-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-46606472015-11-27 Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study Matías-Guiu, Jordi A. Cabrera-Martín, María Nieves Matías-Guiu, Jorge Oreja-Guevara, Celia Riola-Parada, Cristina Moreno-Ramos, Teresa Arrazola, Juan Carreras, José Luis BMC Neurol Research Article BACKGROUND: Positron emission tomography (PET) images with amyloid tracers show normal uptake in healthy white matter, which suggests that amyloid tracers are potentially useful for studying such white matter diseases as multiple sclerosis (MS). METHODS: Twelve patients diagnosed with MS (5 with RRMS, 5 with SPMS, and 2 with PPMS) and 3 healthy controls underwent studies with MRI and (18)F-florbetaben-PET imaging. Images were preprocessed using Statistical Parametric Mapping software. We analysed (18)F-florbetaben uptake in demyelinating plaques (appearing as hyperintense lesions in FLAIR sequences), in normal-appearing white matter, and in grey matter. RESULTS: Mean standardized uptake value relative to cerebellum was higher in normally appearing white matter (NAWM) (1.51 ± 0.12) than in damaged white matter (DWM) (1.24 ± 0.12; P = .002). Mean percentage of change between NAWM and DWM was −17.56 % ± 6.22 %. This percentage of change correlated negatively with EDSS scores (r = −0.61, p < .05) and with age (r = −0.83, p < 0.01). Progressive forms of MS showed a more pronounced reduction of the uptake in DWM in comparison to relapsing-remitting form. CONCLUSIONS: Uptake of (18)F-florbetaben in damaged white matter is lower than that occurring in normally-appearing white matter. These findings indicate that amyloid tracers may be useful in studies of MS, although further research is needed to evaluate the utility of amyloid-PET in monitoring MS progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-015-0502-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-11-25 /pmc/articles/PMC4660647/ /pubmed/26607782 http://dx.doi.org/10.1186/s12883-015-0502-2 Text en © Matías-Guiu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Matías-Guiu, Jordi A.
Cabrera-Martín, María Nieves
Matías-Guiu, Jorge
Oreja-Guevara, Celia
Riola-Parada, Cristina
Moreno-Ramos, Teresa
Arrazola, Juan
Carreras, José Luis
Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study
title Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study
title_full Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study
title_fullStr Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study
title_full_unstemmed Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study
title_short Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study
title_sort amyloid pet imaging in multiple sclerosis: an (18)f-florbetaben study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660647/
https://www.ncbi.nlm.nih.gov/pubmed/26607782
http://dx.doi.org/10.1186/s12883-015-0502-2
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