A promising hypothesis of c-KIT methylation/ expression paradox in c-KIT (+) squamous cell carcinoma of uterine cervix ----- CTCF transcriptional repressor regulates c-KIT proto-oncogene expression

We recently reported one interesting case showing mutation-free c-KIT proto-oncogene overexpression and paradoxical hypermethylation in 54 cases of primary squamous cell carcinoma of uterine cervix (SCC). However, its molecular mechanisms still remain unknown. We propose the hypothesis that increase...

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Detalles Bibliográficos
Autores principales: Chang, Shih-Wen, Chao, Wan-Ru, Ruan, Alexandra, Wang, Po-Hui, Lin, Jau-Chen, Han, Chih-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660683/
https://www.ncbi.nlm.nih.gov/pubmed/26607501
http://dx.doi.org/10.1186/s13000-015-0438-2

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