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Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines

BACKGROUND: Tumour heterogeneity and resistance to systemic treatment in urothelial carcinoma (UC) may arise from cancer stem cells (CSC). A recent model describes cellular differentiation states within UC based on corresponding expression of surface markers (CD) and cytokeratins (CK) with CD90 and...

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Detalles Bibliográficos
Autores principales:	Skowron, Margaretha A., Niegisch, Günter, Fritz, Gerhard, Arent, Tanja, van Roermund, Joep G. H., Romano, Andrea, Albers, Peter, Schulz, Wolfgang A., Hoffmann, Michèle J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660687/ https://www.ncbi.nlm.nih.gov/pubmed/26606927 http://dx.doi.org/10.1186/s13046-015-0259-x

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