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Inflammation and cutaneous nervous system involvement in hypertrophic scarring
This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that infla...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660765/ https://www.ncbi.nlm.nih.gov/pubmed/26692869 http://dx.doi.org/10.4103/1673-5374.167769 |
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author | Li, Shao-hua Yang, Heng-lian Xiao, Hu Wang, Yi-bing Wang, De-chang Huo, Ran |
author_facet | Li, Shao-hua Yang, Heng-lian Xiao, Hu Wang, Yi-bing Wang, De-chang Huo, Ran |
author_sort | Li, Shao-hua |
collection | PubMed |
description | This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation. |
format | Online Article Text |
id | pubmed-4660765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46607652015-12-11 Inflammation and cutaneous nervous system involvement in hypertrophic scarring Li, Shao-hua Yang, Heng-lian Xiao, Hu Wang, Yi-bing Wang, De-chang Huo, Ran Neural Regen Res Research Article This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation. Medknow Publications & Media Pvt Ltd 2015-10 /pmc/articles/PMC4660765/ /pubmed/26692869 http://dx.doi.org/10.4103/1673-5374.167769 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Li, Shao-hua Yang, Heng-lian Xiao, Hu Wang, Yi-bing Wang, De-chang Huo, Ran Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
title | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
title_full | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
title_fullStr | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
title_full_unstemmed | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
title_short | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
title_sort | inflammation and cutaneous nervous system involvement in hypertrophic scarring |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660765/ https://www.ncbi.nlm.nih.gov/pubmed/26692869 http://dx.doi.org/10.4103/1673-5374.167769 |
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