Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells

BACKGROUND: SAMHD1 counteracts HIV-1 or HIV-2/SIVsmm that lacks Vpx by depleting the intracellular pool of nucleotides in myeloid cells and CD4+ quiescent T cells, thereby inhibiting the synthesis of retroviral DNA by reverse transcriptase. Depletion of nucleotides has been shown to underline the es...

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Detalles Bibliográficos
Autores principales: Dragin, Loic, Munir-Matloob, Soundasse, Froehlich, Jeanne, Morel, Marina, Sourisce, Adèle, Lahouassa, Hichem, Bailly, Karine, Mangeney, Marianne, Ramirez, Bertha Cecilia, Margottin-Goguet, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660839/
https://www.ncbi.nlm.nih.gov/pubmed/26606981
http://dx.doi.org/10.1186/s12985-015-0425-y

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