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Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C

BACKGROUND: HIV-1 subtype C Nef sequences have a significantly lower ability overall to down-regulate CD4 and HLA-I than subtype B Nef sequences. Here we investigated whether Nef amino acids differing in frequency between HIV-1 subtypes B and C explain lower CD4 and HLA-I down-regulation ability of...

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Detalles Bibliográficos
Autores principales:	Mann, Jaclyn K., Omarjee, Saleha, Khumalo, Phumzile, Ndung’u, Thumbi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660847/ https://www.ncbi.nlm.nih.gov/pubmed/26607225 http://dx.doi.org/10.1186/s12985-015-0429-7

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