Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides

An improved and efficient method for the synthesis of thioamides is presented. For this transformation, dimethylamine as the key intermediate is generated in situ from dimethylformamide (DMF). All the tested substrates produced the desired products with excellent isolated yields.

Detalles Bibliográficos
Autores principales: Liu, Weibing, Chen, Cui, Liu, Hailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660898/
https://www.ncbi.nlm.nih.gov/pubmed/26664591
http://dx.doi.org/10.3762/bjoc.11.187
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author Liu, Weibing
Chen, Cui
Liu, Hailing
author_facet Liu, Weibing
Chen, Cui
Liu, Hailing
author_sort Liu, Weibing
collection PubMed
description An improved and efficient method for the synthesis of thioamides is presented. For this transformation, dimethylamine as the key intermediate is generated in situ from dimethylformamide (DMF). All the tested substrates produced the desired products with excellent isolated yields.
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spelling pubmed-46608982015-12-09 Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides Liu, Weibing Chen, Cui Liu, Hailing Beilstein J Org Chem Full Research Paper An improved and efficient method for the synthesis of thioamides is presented. For this transformation, dimethylamine as the key intermediate is generated in situ from dimethylformamide (DMF). All the tested substrates produced the desired products with excellent isolated yields. Beilstein-Institut 2015-09-23 /pmc/articles/PMC4660898/ /pubmed/26664591 http://dx.doi.org/10.3762/bjoc.11.187 Text en Copyright © 2015, Liu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Liu, Weibing
Chen, Cui
Liu, Hailing
Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
title Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
title_full Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
title_fullStr Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
title_full_unstemmed Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
title_short Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
title_sort dimethylamine as the key intermediate generated in situ from dimethylformamide (dmf) for the synthesis of thioamides
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660898/
https://www.ncbi.nlm.nih.gov/pubmed/26664591
http://dx.doi.org/10.3762/bjoc.11.187
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AT chencui dimethylamineasthekeyintermediategeneratedinsitufromdimethylformamidedmfforthesynthesisofthioamides
AT liuhailing dimethylamineasthekeyintermediategeneratedinsitufromdimethylformamidedmfforthesynthesisofthioamides

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