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Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

Cytochrome P450 monooxygenases are useful biocatalysts for C–H activation, and there is a need to expand the range of these enzymes beyond what is naturally available. A panel of 93 variants of active self-sufficient P450cam[Tyr96Phe]-RhFRed fusion enzymes with a broad diversity in active site amino...

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Detalles Bibliográficos
Autores principales:	Kelly, Paul P, Eichler, Anja, Herter, Susanne, Kranz, David C, Turner, Nicholas J, Flitsch, Sabine L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2015
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660908/ https://www.ncbi.nlm.nih.gov/pubmed/26664590 http://dx.doi.org/10.3762/bjoc.11.186

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