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Total synthesis of panicein A(2)
The first total synthesis of the unusual aromatic sesquiterpene panicein A(2) is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A(2) exhibits very little antiproliferative activity at...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660959/ https://www.ncbi.nlm.nih.gov/pubmed/26664619 http://dx.doi.org/10.3762/bjoc.11.215 |
| Sumario: | The first total synthesis of the unusual aromatic sesquiterpene panicein A(2) is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A(2) exhibits very little antiproliferative activity at 10 μM – an observation that is at odds with the earlier report that stated panicein A(2) exhibits in vitro cytotoxicity against a number of tumour cell lines. |
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