A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines

An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, N...

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Autores principales: Liu, Mingxing, Li, Jiarong, Chai, Hongxin, Zhang, Kai, Yang, Deli, Zhang, Qi, Shi, Daxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660965/
https://www.ncbi.nlm.nih.gov/pubmed/26664633
http://dx.doi.org/10.3762/bjoc.11.229
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author Liu, Mingxing
Li, Jiarong
Chai, Hongxin
Zhang, Kai
Yang, Deli
Zhang, Qi
Shi, Daxin
author_facet Liu, Mingxing
Li, Jiarong
Chai, Hongxin
Zhang, Kai
Yang, Deli
Zhang, Qi
Shi, Daxin
author_sort Liu, Mingxing
collection PubMed
description An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR ((1)H and (13)C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction.
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spelling pubmed-46609652015-12-09 A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines Liu, Mingxing Li, Jiarong Chai, Hongxin Zhang, Kai Yang, Deli Zhang, Qi Shi, Daxin Beilstein J Org Chem Full Research Paper An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR ((1)H and (13)C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction. Beilstein-Institut 2015-11-06 /pmc/articles/PMC4660965/ /pubmed/26664633 http://dx.doi.org/10.3762/bjoc.11.229 Text en Copyright © 2015, Liu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Liu, Mingxing
Li, Jiarong
Chai, Hongxin
Zhang, Kai
Yang, Deli
Zhang, Qi
Shi, Daxin
A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
title A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
title_full A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
title_fullStr A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
title_full_unstemmed A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
title_short A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
title_sort convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660965/
https://www.ncbi.nlm.nih.gov/pubmed/26664633
http://dx.doi.org/10.3762/bjoc.11.229
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