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Profluorescent substrates for the screening of olefin metathesis catalysts
Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The resu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Beilstein-Institut
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660973/ https://www.ncbi.nlm.nih.gov/pubmed/26664607 http://dx.doi.org/10.3762/bjoc.11.203 |
| _version_ | 1782402911550046208 |
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| author | Reuter, Raphael Ward, Thomas R |
| author_facet | Reuter, Raphael Ward, Thomas R |
| author_sort | Reuter, Raphael |
| collection | PubMed |
| description | Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach. |
| format | Online Article Text |
| id | pubmed-4660973 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46609732015-12-09 Profluorescent substrates for the screening of olefin metathesis catalysts Reuter, Raphael Ward, Thomas R Beilstein J Org Chem Full Research Paper Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach. Beilstein-Institut 2015-10-12 /pmc/articles/PMC4660973/ /pubmed/26664607 http://dx.doi.org/10.3762/bjoc.11.203 Text en Copyright © 2015, Reuter and Ward https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Full Research Paper Reuter, Raphael Ward, Thomas R Profluorescent substrates for the screening of olefin metathesis catalysts |
| title | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_full | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_fullStr | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_full_unstemmed | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_short | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_sort | profluorescent substrates for the screening of olefin metathesis catalysts |
| topic | Full Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660973/ https://www.ncbi.nlm.nih.gov/pubmed/26664607 http://dx.doi.org/10.3762/bjoc.11.203 |
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