Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes

α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free c...

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Detalles Bibliográficos
Autores principales: Zemtsov, Artem A, Volodin, Alexander D, Levin, Vitalij V, Struchkova, Marina I, Dilman, Alexander D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660974/
https://www.ncbi.nlm.nih.gov/pubmed/26664635
http://dx.doi.org/10.3762/bjoc.11.231
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author Zemtsov, Artem A
Volodin, Alexander D
Levin, Vitalij V
Struchkova, Marina I
Dilman, Alexander D
author_facet Zemtsov, Artem A
Volodin, Alexander D
Levin, Vitalij V
Struchkova, Marina I
Dilman, Alexander D
author_sort Zemtsov, Artem A
collection PubMed
description α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free conditions.
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spelling pubmed-46609742015-12-09 Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes Zemtsov, Artem A Volodin, Alexander D Levin, Vitalij V Struchkova, Marina I Dilman, Alexander D Beilstein J Org Chem Letter α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free conditions. Beilstein-Institut 2015-11-10 /pmc/articles/PMC4660974/ /pubmed/26664635 http://dx.doi.org/10.3762/bjoc.11.231 Text en Copyright © 2015, Zemtsov et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Zemtsov, Artem A
Volodin, Alexander D
Levin, Vitalij V
Struchkova, Marina I
Dilman, Alexander D
Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
title Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
title_full Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
title_fullStr Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
title_full_unstemmed Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
title_short Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
title_sort coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660974/
https://www.ncbi.nlm.nih.gov/pubmed/26664635
http://dx.doi.org/10.3762/bjoc.11.231
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