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Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis

[Image: see text] Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis (Msmeg) can grow on cholesterol as the sole carbon source. In Mtb the utilization of cholesterol can be initiated by CYP125A1 or CYP142A1 and in Msmeg by the orthologous CYP125A3 and CYP142A2. Double knockout of the two e...

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Detalles Bibliográficos
Autores principales: Frank, Daniel J., Waddling, Christopher A., La, Maggie, Ortiz de Montellano, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660985/
https://www.ncbi.nlm.nih.gov/pubmed/26522442
http://dx.doi.org/10.1021/acs.biochem.5b01029

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