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POD-1/Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells
During gonad and adrenal development, the POD-1/capsulin/TCF21transcription factor negatively regulates SF-1/NR5A1expression, with higher SF-1 levels being associated with increased adrenal cell proliferation and tumorigenesis. In adrenocortical tumor cells, POD-1 binds to the SF-1 E-box promoter re...
Autores principales: | França, M. M., Abreu, N. P., Vrechi, T. A. M., Lotfi, C. F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661024/ https://www.ncbi.nlm.nih.gov/pubmed/26421867 http://dx.doi.org/10.1590/1414-431X20154748 |
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