G9a Is Essential for Epigenetic Silencing of K(+) Channel Genes in Acute-to-Chronic Pain Transition

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a long-lasting reduction in K(+) channel expression in the dorsal root ganglion (DRG), but little is known about the epigenetic mechanisms involved. Here we show that nerve injury increased H3K9me2 occupa...

Descripción completa

Detalles Bibliográficos
Autores principales: Laumet, Geoffroy, Garriga, Judit, Chen, Shao-Rui, Zhang, Yuhao, Li, De-Pei, Smith, Trevor M., Dong, Yingchun, Jelinek, Jaroslav, Cesaroni, Matteo, Issa, Jean-Pierre, Pan, Hui-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086/
https://www.ncbi.nlm.nih.gov/pubmed/26551542
http://dx.doi.org/10.1038/nn.4165

Ejemplares similares

Ejemplares similares