Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered bi-potent, as they only produce neurons and astrocytes in vivo. Here we show in mouse that inactivation of neurofibromin 1, a gene mutated in neurofibromatosis type 1, unlocks a latent oligodendrocyte lineage potential to pr...

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Detalles Bibliográficos
Autores principales: Sun, Gerald J., Zhou, Yi, Ito, Shiori, Bonaguidi, Michael A., Stein-O’Brien, Genevieve, Kawasaki, Nicholas, Modak, Nikhil, Zhu, Yuan, Ming, Guo-li, Song, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661096/
https://www.ncbi.nlm.nih.gov/pubmed/26523645
http://dx.doi.org/10.1038/nn.4159
Descripción
Sumario:Endogenous neural stem cells (NSCs) in the adult hippocampus are considered bi-potent, as they only produce neurons and astrocytes in vivo. Here we show in mouse that inactivation of neurofibromin 1, a gene mutated in neurofibromatosis type 1, unlocks a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue to promote stem cell plasticity by targeting barriers of latent lineage potential.

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