Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered bi-potent, as they only produce neurons and astrocytes in vivo. Here we show in mouse that inactivation of neurofibromin 1, a gene mutated in neurofibromatosis type 1, unlocks a latent oligodendrocyte lineage potential to pr...

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Autores principales: Sun, Gerald J., Zhou, Yi, Ito, Shiori, Bonaguidi, Michael A., Stein-O’Brien, Genevieve, Kawasaki, Nicholas, Modak, Nikhil, Zhu, Yuan, Ming, Guo-li, Song, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661096/
https://www.ncbi.nlm.nih.gov/pubmed/26523645
http://dx.doi.org/10.1038/nn.4159
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author Sun, Gerald J.
Zhou, Yi
Ito, Shiori
Bonaguidi, Michael A.
Stein-O’Brien, Genevieve
Kawasaki, Nicholas
Modak, Nikhil
Zhu, Yuan
Ming, Guo-li
Song, Hongjun
author_facet Sun, Gerald J.
Zhou, Yi
Ito, Shiori
Bonaguidi, Michael A.
Stein-O’Brien, Genevieve
Kawasaki, Nicholas
Modak, Nikhil
Zhu, Yuan
Ming, Guo-li
Song, Hongjun
author_sort Sun, Gerald J.
collection PubMed
description Endogenous neural stem cells (NSCs) in the adult hippocampus are considered bi-potent, as they only produce neurons and astrocytes in vivo. Here we show in mouse that inactivation of neurofibromin 1, a gene mutated in neurofibromatosis type 1, unlocks a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue to promote stem cell plasticity by targeting barriers of latent lineage potential.
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spelling pubmed-46610962016-05-18 Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation Sun, Gerald J. Zhou, Yi Ito, Shiori Bonaguidi, Michael A. Stein-O’Brien, Genevieve Kawasaki, Nicholas Modak, Nikhil Zhu, Yuan Ming, Guo-li Song, Hongjun Nat Neurosci Article Endogenous neural stem cells (NSCs) in the adult hippocampus are considered bi-potent, as they only produce neurons and astrocytes in vivo. Here we show in mouse that inactivation of neurofibromin 1, a gene mutated in neurofibromatosis type 1, unlocks a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue to promote stem cell plasticity by targeting barriers of latent lineage potential. 2015-11-02 2015-12 /pmc/articles/PMC4661096/ /pubmed/26523645 http://dx.doi.org/10.1038/nn.4159 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Sun, Gerald J.
Zhou, Yi
Ito, Shiori
Bonaguidi, Michael A.
Stein-O’Brien, Genevieve
Kawasaki, Nicholas
Modak, Nikhil
Zhu, Yuan
Ming, Guo-li
Song, Hongjun
Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
title Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
title_full Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
title_fullStr Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
title_full_unstemmed Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
title_short Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
title_sort latent tri-lineage potential of adult hippocampal neural stem cells revealed by nf1 inactivation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661096/
https://www.ncbi.nlm.nih.gov/pubmed/26523645
http://dx.doi.org/10.1038/nn.4159
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