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The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis
Angiogenesis, or the formation of new microvasculature, is a physiological process that may occur in the setting of chronic tissue ischemia and can play an important role in improving tissue perfusion and blood flow following myocardial infarction or in the presence of peripheral vascular disease (P...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661208/ https://www.ncbi.nlm.nih.gov/pubmed/25750124 http://dx.doi.org/10.1007/s12149-015-0961-y |
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author | Stacy, Mitchel R. Paeng, Jin Chul Sinusas, Albert J. |
author_facet | Stacy, Mitchel R. Paeng, Jin Chul Sinusas, Albert J. |
author_sort | Stacy, Mitchel R. |
collection | PubMed |
description | Angiogenesis, or the formation of new microvasculature, is a physiological process that may occur in the setting of chronic tissue ischemia and can play an important role in improving tissue perfusion and blood flow following myocardial infarction or in the presence of peripheral vascular disease (PVD). Molecular imaging of angiogenesis within the cardiovascular system is a developing field of study. Targeted imaging of angiogenesis has the potential for non-invasive assessment of the underlying molecular signaling events associated with the angiogenic process and, when applied in conjunction with physiological perfusion imaging, may be utilized to predict and evaluate clinical outcomes in the setting of ischemic heart disease or PVD. This review discusses the developing radiotracer-based imaging techniques and technology currently in use that possess potential for clinical translation, with specific focus on PET and SPECT imaging of myocardial and peripheral angiogenesis. |
format | Online Article Text |
id | pubmed-4661208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-46612082015-12-04 The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis Stacy, Mitchel R. Paeng, Jin Chul Sinusas, Albert J. Ann Nucl Med Invited Review Article Angiogenesis, or the formation of new microvasculature, is a physiological process that may occur in the setting of chronic tissue ischemia and can play an important role in improving tissue perfusion and blood flow following myocardial infarction or in the presence of peripheral vascular disease (PVD). Molecular imaging of angiogenesis within the cardiovascular system is a developing field of study. Targeted imaging of angiogenesis has the potential for non-invasive assessment of the underlying molecular signaling events associated with the angiogenic process and, when applied in conjunction with physiological perfusion imaging, may be utilized to predict and evaluate clinical outcomes in the setting of ischemic heart disease or PVD. This review discusses the developing radiotracer-based imaging techniques and technology currently in use that possess potential for clinical translation, with specific focus on PET and SPECT imaging of myocardial and peripheral angiogenesis. Springer Japan 2015-03-08 2015 /pmc/articles/PMC4661208/ /pubmed/25750124 http://dx.doi.org/10.1007/s12149-015-0961-y Text en © The Japanese Society of Nuclear Medicine 2015 |
spellingShingle | Invited Review Article Stacy, Mitchel R. Paeng, Jin Chul Sinusas, Albert J. The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
title | The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
title_full | The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
title_fullStr | The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
title_full_unstemmed | The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
title_short | The role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
title_sort | role of molecular imaging in the evaluation of myocardial and peripheral angiogenesis |
topic | Invited Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661208/ https://www.ncbi.nlm.nih.gov/pubmed/25750124 http://dx.doi.org/10.1007/s12149-015-0961-y |
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