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Uncovering the Mechanism of Aggregation of Human Transthyretin

The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis. The standard treatment of familial cases of TTR amyloidosis...

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Detalles Bibliográficos
Autores principales:	Saelices, Lorena, Johnson, Lisa M., Liang, Wilson Y., Sawaya, Michael R., Cascio, Duilio, Ruchala, Piotr, Whitelegge, Julian, Jiang, Lin, Riek, Roland, Eisenberg, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661406/ https://www.ncbi.nlm.nih.gov/pubmed/26459562 http://dx.doi.org/10.1074/jbc.M115.659912

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