Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

In mice, the deletion of either Mdm2 or Mdm4 results in a p53-dependent embryonic lethality. We used zinc-finger nucleases to construct mutations in the mdm2 and mdm4 genes of zebrafish. Although the loss of mdm2 results in a p53-dependent early embryonic lethality, mdm4 mutant fish are viable and g...

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Detalles Bibliográficos
Autores principales: Chua, J S, Liew, H P, Guo, L, Lane, D P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661431/
https://www.ncbi.nlm.nih.gov/pubmed/25746004
http://dx.doi.org/10.1038/onc.2015.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661431/
https://www.ncbi.nlm.nih.gov/pubmed/25746004
http://dx.doi.org/10.1038/onc.2015.57

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