In vitro follicle growth supports human oocyte meiotic maturation

In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles...

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Detalles Bibliográficos
Autores principales: Xiao, Shuo, Zhang, Jiyang, Romero, Megan M., Smith, Kristin N., Shea, Lonnie D., Woodruff, Teresa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661442/
https://www.ncbi.nlm.nih.gov/pubmed/26612176
http://dx.doi.org/10.1038/srep17323
Descripción
Sumario:In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles developed from the preantral to antral stage, and, for the first time, produced meiotically competent metaphase II (MII) oocytes after in vitro maturation (IVM).

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