Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton

Fusicoccane diterpenoids usually possess a fused 5-8-5 tricyclic ring system, which are biogenetically generated from geranylgeranyl diphosphate (GGDP). In our report, three novel diterpenoid alkaloids with fusicoccane skeleton, pericolactines A–C (1–3), were isolated from Periconia sp.. Their struc...

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Autores principales: Wu, Yue-Hua, Chen, Guo-Dong, He, Rong-Rong, Wang, Chuan-Xi, Hu, Dan, Wang, Gao-Qian, Guo, Liang-Dong, Yao, Xin-Sheng, Gao, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661464/
https://www.ncbi.nlm.nih.gov/pubmed/26611465
http://dx.doi.org/10.1038/srep17082
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author Wu, Yue-Hua
Chen, Guo-Dong
He, Rong-Rong
Wang, Chuan-Xi
Hu, Dan
Wang, Gao-Qian
Guo, Liang-Dong
Yao, Xin-Sheng
Gao, Hao
author_facet Wu, Yue-Hua
Chen, Guo-Dong
He, Rong-Rong
Wang, Chuan-Xi
Hu, Dan
Wang, Gao-Qian
Guo, Liang-Dong
Yao, Xin-Sheng
Gao, Hao
author_sort Wu, Yue-Hua
collection PubMed
description Fusicoccane diterpenoids usually possess a fused 5-8-5 tricyclic ring system, which are biogenetically generated from geranylgeranyl diphosphate (GGDP). In our report, three novel diterpenoid alkaloids with fusicoccane skeleton, pericolactines A–C (1–3), were isolated from Periconia sp.. Their structures with absolute configurations were determined by spectroscopic analyses and quantum chemical ECD calculation. Pericolactines A–C (1–3) are a new class of diterpenoid alkaloids with an unusual fused 5-5-8-5 tetracyclic ring system, which derive from a geranylgeranyl diphosphate (GGDP) and serine conjugated biosynthesis. They belong to the atypical diterpenoid alkaloids.
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spelling pubmed-46614642015-12-02 Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton Wu, Yue-Hua Chen, Guo-Dong He, Rong-Rong Wang, Chuan-Xi Hu, Dan Wang, Gao-Qian Guo, Liang-Dong Yao, Xin-Sheng Gao, Hao Sci Rep Article Fusicoccane diterpenoids usually possess a fused 5-8-5 tricyclic ring system, which are biogenetically generated from geranylgeranyl diphosphate (GGDP). In our report, three novel diterpenoid alkaloids with fusicoccane skeleton, pericolactines A–C (1–3), were isolated from Periconia sp.. Their structures with absolute configurations were determined by spectroscopic analyses and quantum chemical ECD calculation. Pericolactines A–C (1–3) are a new class of diterpenoid alkaloids with an unusual fused 5-5-8-5 tetracyclic ring system, which derive from a geranylgeranyl diphosphate (GGDP) and serine conjugated biosynthesis. They belong to the atypical diterpenoid alkaloids. Nature Publishing Group 2015-11-27 /pmc/articles/PMC4661464/ /pubmed/26611465 http://dx.doi.org/10.1038/srep17082 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wu, Yue-Hua
Chen, Guo-Dong
He, Rong-Rong
Wang, Chuan-Xi
Hu, Dan
Wang, Gao-Qian
Guo, Liang-Dong
Yao, Xin-Sheng
Gao, Hao
Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton
title Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton
title_full Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton
title_fullStr Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton
title_full_unstemmed Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton
title_short Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton
title_sort pericolactines a–c, a new class of diterpenoid alkaloids with unusual tetracyclic skeleton
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661464/
https://www.ncbi.nlm.nih.gov/pubmed/26611465
http://dx.doi.org/10.1038/srep17082
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