Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch

Salt bridges in lipid bilayers play a decisive role in the dynamic assembly and downstream signaling of the natural killer and T-cell receptors. Here, we describe the identification of an inter-subunit salt bridge in the membrane within yet another key component of the immune system, the peptide-loa...

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Detalles Bibliográficos
Autores principales: Blees, Andreas, Reichel, Katrin, Trowitzsch, Simon, Fisette, Olivier, Bock, Christoph, Abele, Rupert, Hummer, Gerhard, Schäfer, Lars V., Tampé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661472/
https://www.ncbi.nlm.nih.gov/pubmed/26611325
http://dx.doi.org/10.1038/srep17341

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