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A novel approach to study oxidative stress in neonatal respiratory distress syndrome
BACKGROUND: Respiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661505/ https://www.ncbi.nlm.nih.gov/pubmed/26676080 http://dx.doi.org/10.1016/j.bbacli.2014.12.001 |
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author | Negi, Reena Pande, Deepti Karki, Kanchan Kumar, Ashok Khanna, Ranjana S. Khanna, Hari D. |
author_facet | Negi, Reena Pande, Deepti Karki, Kanchan Kumar, Ashok Khanna, Ranjana S. Khanna, Hari D. |
author_sort | Negi, Reena |
collection | PubMed |
description | BACKGROUND: Respiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the development of neonatal RDS. METHODS: Markers of oxidative stress and antioxidant activity in umbilical cord blood were studied in infants with neonatal respiratory distress syndrome with reference to healthy newborns. RESULTS: Status of markers of oxidative stress (malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxy guanosine) showed a significant increase with depleted levels of total antioxidant capacity in neonatal RDS when compared to healthy newborns. CONCLUSION: The study provides convincing evidence of oxidative damage and diminished antioxidant defenses in newborns with RDS. Neonatal RDS is characterized by damage of lipid, protein and DNA, which indicates the augmentation of oxidative stress. GENERAL SIGNIFICANCE: The identification of the potential biomarker of oxidative stress consists of a promising strategy to study the pathophysiology of neonatal RDS. |
format | Online Article Text |
id | pubmed-4661505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-46615052015-12-15 A novel approach to study oxidative stress in neonatal respiratory distress syndrome Negi, Reena Pande, Deepti Karki, Kanchan Kumar, Ashok Khanna, Ranjana S. Khanna, Hari D. BBA Clin Regular Article BACKGROUND: Respiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the development of neonatal RDS. METHODS: Markers of oxidative stress and antioxidant activity in umbilical cord blood were studied in infants with neonatal respiratory distress syndrome with reference to healthy newborns. RESULTS: Status of markers of oxidative stress (malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxy guanosine) showed a significant increase with depleted levels of total antioxidant capacity in neonatal RDS when compared to healthy newborns. CONCLUSION: The study provides convincing evidence of oxidative damage and diminished antioxidant defenses in newborns with RDS. Neonatal RDS is characterized by damage of lipid, protein and DNA, which indicates the augmentation of oxidative stress. GENERAL SIGNIFICANCE: The identification of the potential biomarker of oxidative stress consists of a promising strategy to study the pathophysiology of neonatal RDS. Elsevier 2014-12-08 /pmc/articles/PMC4661505/ /pubmed/26676080 http://dx.doi.org/10.1016/j.bbacli.2014.12.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Negi, Reena Pande, Deepti Karki, Kanchan Kumar, Ashok Khanna, Ranjana S. Khanna, Hari D. A novel approach to study oxidative stress in neonatal respiratory distress syndrome |
title | A novel approach to study oxidative stress in neonatal respiratory distress syndrome |
title_full | A novel approach to study oxidative stress in neonatal respiratory distress syndrome |
title_fullStr | A novel approach to study oxidative stress in neonatal respiratory distress syndrome |
title_full_unstemmed | A novel approach to study oxidative stress in neonatal respiratory distress syndrome |
title_short | A novel approach to study oxidative stress in neonatal respiratory distress syndrome |
title_sort | novel approach to study oxidative stress in neonatal respiratory distress syndrome |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661505/ https://www.ncbi.nlm.nih.gov/pubmed/26676080 http://dx.doi.org/10.1016/j.bbacli.2014.12.001 |
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