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Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh

In earlier analyses, we demonstrated dose-response relationships between renal and lung cancer and local arsenic concentrations in wells used by Bangladeshi villagers. We used the same case-referent approach to examine the relation of arsenic to biopsy confirmed transition cell cancer (TCC) of the u...

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Autores principales: Mostafa, Mohammad Golam, Cherry, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661611/
https://www.ncbi.nlm.nih.gov/pubmed/26516891
http://dx.doi.org/10.3390/ijerph121113739
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author Mostafa, Mohammad Golam
Cherry, Nicola
author_facet Mostafa, Mohammad Golam
Cherry, Nicola
author_sort Mostafa, Mohammad Golam
collection PubMed
description In earlier analyses, we demonstrated dose-response relationships between renal and lung cancer and local arsenic concentrations in wells used by Bangladeshi villagers. We used the same case-referent approach to examine the relation of arsenic to biopsy confirmed transition cell cancer (TCC) of the ureter, bladder or urethra in these villagers. As the International Agency for Research on Cancer (IARC) has conclude that arsenic in drinking water causes bladder cancer, we expected to find higher risk with increasing arsenic concentration. We used histology/cytology results from biopsies carried out at a single clinic in Dhaka, Bangladesh from January 2008 to October 2011. We classified these into four groups, TCC (n = 1466), other malignancies (n = 145), chronic cystitis (CC) (n = 844) and other benign (n = 194). Arsenic concentration was estimated from British Geological Survey reports. Odds ratios were calculated by multilevel logistic regression adjusted for confounding and allowing for geographic clustering. We found no consistent trend for TCC with increasing arsenic concentration but the likelihood of a patient with benign disease having CC was significantly increased at arsenic concentrations >100 µg/L. We conclude that the expected relationship of TCC to arsenic was masked by over-matching that resulted from the previously unreported relationship between arsenic and CC. We hypothesize that CC may be a precursor of TCC in high arsenic areas.
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spelling pubmed-46616112015-12-10 Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh Mostafa, Mohammad Golam Cherry, Nicola Int J Environ Res Public Health Article In earlier analyses, we demonstrated dose-response relationships between renal and lung cancer and local arsenic concentrations in wells used by Bangladeshi villagers. We used the same case-referent approach to examine the relation of arsenic to biopsy confirmed transition cell cancer (TCC) of the ureter, bladder or urethra in these villagers. As the International Agency for Research on Cancer (IARC) has conclude that arsenic in drinking water causes bladder cancer, we expected to find higher risk with increasing arsenic concentration. We used histology/cytology results from biopsies carried out at a single clinic in Dhaka, Bangladesh from January 2008 to October 2011. We classified these into four groups, TCC (n = 1466), other malignancies (n = 145), chronic cystitis (CC) (n = 844) and other benign (n = 194). Arsenic concentration was estimated from British Geological Survey reports. Odds ratios were calculated by multilevel logistic regression adjusted for confounding and allowing for geographic clustering. We found no consistent trend for TCC with increasing arsenic concentration but the likelihood of a patient with benign disease having CC was significantly increased at arsenic concentrations >100 µg/L. We conclude that the expected relationship of TCC to arsenic was masked by over-matching that resulted from the previously unreported relationship between arsenic and CC. We hypothesize that CC may be a precursor of TCC in high arsenic areas. MDPI 2015-10-28 2015-11 /pmc/articles/PMC4661611/ /pubmed/26516891 http://dx.doi.org/10.3390/ijerph121113739 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mostafa, Mohammad Golam
Cherry, Nicola
Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
title Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
title_full Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
title_fullStr Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
title_full_unstemmed Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
title_short Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh
title_sort arsenic in drinking water, transition cell cancer and chronic cystitis in rural bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661611/
https://www.ncbi.nlm.nih.gov/pubmed/26516891
http://dx.doi.org/10.3390/ijerph121113739
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