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Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China

Objective: To estimate the disease burden and financial burden attributed to hepatitis B virus (HBV) infection in Guangdong Province. Methods: Based on the data of incidence, mortality and healthcare cost of HBV-related diseases and other socio-economic data in Guangdong Province, we estimated death...

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Autores principales: Xiao, Jianpeng, Lin, Hualiang, Liu, Tao, Zeng, Weilin, Li, Xing, Shao, Xiaoping, Tan, Qiu, Xu, Yanjun, Xu, Xiaojun, Zheng, Huizhen, Ma, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661632/
https://www.ncbi.nlm.nih.gov/pubmed/26540065
http://dx.doi.org/10.3390/ijerph121114055
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author Xiao, Jianpeng
Lin, Hualiang
Liu, Tao
Zeng, Weilin
Li, Xing
Shao, Xiaoping
Tan, Qiu
Xu, Yanjun
Xu, Xiaojun
Zheng, Huizhen
Ma, Wenjun
author_facet Xiao, Jianpeng
Lin, Hualiang
Liu, Tao
Zeng, Weilin
Li, Xing
Shao, Xiaoping
Tan, Qiu
Xu, Yanjun
Xu, Xiaojun
Zheng, Huizhen
Ma, Wenjun
author_sort Xiao, Jianpeng
collection PubMed
description Objective: To estimate the disease burden and financial burden attributed to hepatitis B virus (HBV) infection in Guangdong Province. Methods: Based on the data of incidence, mortality and healthcare cost of HBV-related diseases and other socio-economic data in Guangdong Province, we estimated deaths, disability-adjusted life-years (DALYs) and economic cost for the three HBV-related diseases—hepatitis B, liver cirrhosis and liver cancer—in Guangdong following the procedures developed for the global burden of disease study. Then disease burden and economic cost attributed to HBV infection was estimated. Results: HBV infection was estimated to have caused 33,600 (95% confidence interval (CI): 29,300–37,800) premature deaths and the loss of 583,200 (95% CI: 495,200–671,100) DALYs in Guangdong in 2005. The greatest loss of deaths and DALYs were from liver cancer. The 45–59 years age group had the greatest burden attributable to HBV infection. The estimated total annual cost of HBV-related diseases in Guangdong was RMB 10.8 (95% CI: 8.7–13.0) billion,the direct and indirect cost were RMB 2.6 (95% CI: 2.1–3.2) and 8.2 (95% CI: 6.6–9.8) billion. Conclusions: HBV infection is a great medical challenge as well as a significant economic burden to Guangdong Province. The results suggest that substantial health benefits could be gained by extending effective public health and clinical interventions to reduce HBV infection in Guangdong Province.
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spelling pubmed-46616322015-12-10 Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China Xiao, Jianpeng Lin, Hualiang Liu, Tao Zeng, Weilin Li, Xing Shao, Xiaoping Tan, Qiu Xu, Yanjun Xu, Xiaojun Zheng, Huizhen Ma, Wenjun Int J Environ Res Public Health Article Objective: To estimate the disease burden and financial burden attributed to hepatitis B virus (HBV) infection in Guangdong Province. Methods: Based on the data of incidence, mortality and healthcare cost of HBV-related diseases and other socio-economic data in Guangdong Province, we estimated deaths, disability-adjusted life-years (DALYs) and economic cost for the three HBV-related diseases—hepatitis B, liver cirrhosis and liver cancer—in Guangdong following the procedures developed for the global burden of disease study. Then disease burden and economic cost attributed to HBV infection was estimated. Results: HBV infection was estimated to have caused 33,600 (95% confidence interval (CI): 29,300–37,800) premature deaths and the loss of 583,200 (95% CI: 495,200–671,100) DALYs in Guangdong in 2005. The greatest loss of deaths and DALYs were from liver cancer. The 45–59 years age group had the greatest burden attributable to HBV infection. The estimated total annual cost of HBV-related diseases in Guangdong was RMB 10.8 (95% CI: 8.7–13.0) billion,the direct and indirect cost were RMB 2.6 (95% CI: 2.1–3.2) and 8.2 (95% CI: 6.6–9.8) billion. Conclusions: HBV infection is a great medical challenge as well as a significant economic burden to Guangdong Province. The results suggest that substantial health benefits could be gained by extending effective public health and clinical interventions to reduce HBV infection in Guangdong Province. MDPI 2015-11-02 2015-11 /pmc/articles/PMC4661632/ /pubmed/26540065 http://dx.doi.org/10.3390/ijerph121114055 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xiao, Jianpeng
Lin, Hualiang
Liu, Tao
Zeng, Weilin
Li, Xing
Shao, Xiaoping
Tan, Qiu
Xu, Yanjun
Xu, Xiaojun
Zheng, Huizhen
Ma, Wenjun
Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China
title Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China
title_full Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China
title_fullStr Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China
title_full_unstemmed Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China
title_short Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China
title_sort disease burden from hepatitis b virus infection in guangdong province, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661632/
https://www.ncbi.nlm.nih.gov/pubmed/26540065
http://dx.doi.org/10.3390/ijerph121114055
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