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Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease

Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography wer...

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Autores principales: Zhang, Huiping, Liu, Mengxue, Ren, Tiantian, Wang, Xiangqian, Liu, Dandan, Xu, Mingliang, Han, LingFei, Wu, Zewei, Li, Haibo, Zhu, Yu, Wen, Yufeng, Sun, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661646/
https://www.ncbi.nlm.nih.gov/pubmed/26569275
http://dx.doi.org/10.3390/ijerph121114275
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author Zhang, Huiping
Liu, Mengxue
Ren, Tiantian
Wang, Xiangqian
Liu, Dandan
Xu, Mingliang
Han, LingFei
Wu, Zewei
Li, Haibo
Zhu, Yu
Wen, Yufeng
Sun, Wenjie
author_facet Zhang, Huiping
Liu, Mengxue
Ren, Tiantian
Wang, Xiangqian
Liu, Dandan
Xu, Mingliang
Han, LingFei
Wu, Zewei
Li, Haibo
Zhu, Yu
Wen, Yufeng
Sun, Wenjie
author_sort Zhang, Huiping
collection PubMed
description Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography were divided into two groups depending on the presence of CHD. PS, carotid intima-media thickness, and carotid blood flow were measured. Receiver operating characteristic curve analysis was performed to establish the best prediction model for CHD presence. Results: Age, sex, carotid intima-media thickness of internal carotid artery and carotid bifurcation, PS, peak systolic velocity (PSA) of right internal carotid artery (RICA), and most resistance index data were significantly related with the presence of CHD. The area under the curve for a collective model, which included factors of the PS, carotid hemodynamics and age, was significantly higher than the other model. Age, PS, and PSA of RICA were significant contributors for predicting CHD presence. Conclusions: The model of PS and PSA of RICA has greater predictive value for CHD than PS alone. Adding age to PS and PSA of RICA further improves predictive value over PS alone.
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spelling pubmed-46616462015-12-10 Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease Zhang, Huiping Liu, Mengxue Ren, Tiantian Wang, Xiangqian Liu, Dandan Xu, Mingliang Han, LingFei Wu, Zewei Li, Haibo Zhu, Yu Wen, Yufeng Sun, Wenjie Int J Environ Res Public Health Article Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography were divided into two groups depending on the presence of CHD. PS, carotid intima-media thickness, and carotid blood flow were measured. Receiver operating characteristic curve analysis was performed to establish the best prediction model for CHD presence. Results: Age, sex, carotid intima-media thickness of internal carotid artery and carotid bifurcation, PS, peak systolic velocity (PSA) of right internal carotid artery (RICA), and most resistance index data were significantly related with the presence of CHD. The area under the curve for a collective model, which included factors of the PS, carotid hemodynamics and age, was significantly higher than the other model. Age, PS, and PSA of RICA were significant contributors for predicting CHD presence. Conclusions: The model of PS and PSA of RICA has greater predictive value for CHD than PS alone. Adding age to PS and PSA of RICA further improves predictive value over PS alone. MDPI 2015-11-09 2015-11 /pmc/articles/PMC4661646/ /pubmed/26569275 http://dx.doi.org/10.3390/ijerph121114275 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Huiping
Liu, Mengxue
Ren, Tiantian
Wang, Xiangqian
Liu, Dandan
Xu, Mingliang
Han, LingFei
Wu, Zewei
Li, Haibo
Zhu, Yu
Wen, Yufeng
Sun, Wenjie
Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
title Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
title_full Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
title_fullStr Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
title_full_unstemmed Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
title_short Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
title_sort associations between carotid artery plaque score, carotid hemodynamics and coronary heart disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661646/
https://www.ncbi.nlm.nih.gov/pubmed/26569275
http://dx.doi.org/10.3390/ijerph121114275
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