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Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease
Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography wer...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661646/ https://www.ncbi.nlm.nih.gov/pubmed/26569275 http://dx.doi.org/10.3390/ijerph121114275 |
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author | Zhang, Huiping Liu, Mengxue Ren, Tiantian Wang, Xiangqian Liu, Dandan Xu, Mingliang Han, LingFei Wu, Zewei Li, Haibo Zhu, Yu Wen, Yufeng Sun, Wenjie |
author_facet | Zhang, Huiping Liu, Mengxue Ren, Tiantian Wang, Xiangqian Liu, Dandan Xu, Mingliang Han, LingFei Wu, Zewei Li, Haibo Zhu, Yu Wen, Yufeng Sun, Wenjie |
author_sort | Zhang, Huiping |
collection | PubMed |
description | Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography were divided into two groups depending on the presence of CHD. PS, carotid intima-media thickness, and carotid blood flow were measured. Receiver operating characteristic curve analysis was performed to establish the best prediction model for CHD presence. Results: Age, sex, carotid intima-media thickness of internal carotid artery and carotid bifurcation, PS, peak systolic velocity (PSA) of right internal carotid artery (RICA), and most resistance index data were significantly related with the presence of CHD. The area under the curve for a collective model, which included factors of the PS, carotid hemodynamics and age, was significantly higher than the other model. Age, PS, and PSA of RICA were significant contributors for predicting CHD presence. Conclusions: The model of PS and PSA of RICA has greater predictive value for CHD than PS alone. Adding age to PS and PSA of RICA further improves predictive value over PS alone. |
format | Online Article Text |
id | pubmed-4661646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46616462015-12-10 Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease Zhang, Huiping Liu, Mengxue Ren, Tiantian Wang, Xiangqian Liu, Dandan Xu, Mingliang Han, LingFei Wu, Zewei Li, Haibo Zhu, Yu Wen, Yufeng Sun, Wenjie Int J Environ Res Public Health Article Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography were divided into two groups depending on the presence of CHD. PS, carotid intima-media thickness, and carotid blood flow were measured. Receiver operating characteristic curve analysis was performed to establish the best prediction model for CHD presence. Results: Age, sex, carotid intima-media thickness of internal carotid artery and carotid bifurcation, PS, peak systolic velocity (PSA) of right internal carotid artery (RICA), and most resistance index data were significantly related with the presence of CHD. The area under the curve for a collective model, which included factors of the PS, carotid hemodynamics and age, was significantly higher than the other model. Age, PS, and PSA of RICA were significant contributors for predicting CHD presence. Conclusions: The model of PS and PSA of RICA has greater predictive value for CHD than PS alone. Adding age to PS and PSA of RICA further improves predictive value over PS alone. MDPI 2015-11-09 2015-11 /pmc/articles/PMC4661646/ /pubmed/26569275 http://dx.doi.org/10.3390/ijerph121114275 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Huiping Liu, Mengxue Ren, Tiantian Wang, Xiangqian Liu, Dandan Xu, Mingliang Han, LingFei Wu, Zewei Li, Haibo Zhu, Yu Wen, Yufeng Sun, Wenjie Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease |
title | Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease |
title_full | Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease |
title_fullStr | Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease |
title_full_unstemmed | Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease |
title_short | Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease |
title_sort | associations between carotid artery plaque score, carotid hemodynamics and coronary heart disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661646/ https://www.ncbi.nlm.nih.gov/pubmed/26569275 http://dx.doi.org/10.3390/ijerph121114275 |
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