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The Estrogen Receptor-β Expression in De Quervain’s Disease

Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation...

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Autores principales: Shen, Po-Chuan, Wang, Ping-Hui, Wu, Po-Ting, Wu, Kuo-Chen, Hsieh, Jeng-Long, Jou, I-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661827/
https://www.ncbi.nlm.nih.gov/pubmed/26556342
http://dx.doi.org/10.3390/ijms161125968
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author Shen, Po-Chuan
Wang, Ping-Hui
Wu, Po-Ting
Wu, Kuo-Chen
Hsieh, Jeng-Long
Jou, I-Ming
author_facet Shen, Po-Chuan
Wang, Ping-Hui
Wu, Po-Ting
Wu, Kuo-Chen
Hsieh, Jeng-Long
Jou, I-Ming
author_sort Shen, Po-Chuan
collection PubMed
description Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain’s. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand’s factor (vWF). De Quervain’s occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors—IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain’s disease is. ER-β might be a useful target for novel de Quervain’s disease therapy.
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spelling pubmed-46618272015-12-10 The Estrogen Receptor-β Expression in De Quervain’s Disease Shen, Po-Chuan Wang, Ping-Hui Wu, Po-Ting Wu, Kuo-Chen Hsieh, Jeng-Long Jou, I-Ming Int J Mol Sci Article Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain’s. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand’s factor (vWF). De Quervain’s occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors—IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain’s disease is. ER-β might be a useful target for novel de Quervain’s disease therapy. MDPI 2015-11-04 /pmc/articles/PMC4661827/ /pubmed/26556342 http://dx.doi.org/10.3390/ijms161125968 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shen, Po-Chuan
Wang, Ping-Hui
Wu, Po-Ting
Wu, Kuo-Chen
Hsieh, Jeng-Long
Jou, I-Ming
The Estrogen Receptor-β Expression in De Quervain’s Disease
title The Estrogen Receptor-β Expression in De Quervain’s Disease
title_full The Estrogen Receptor-β Expression in De Quervain’s Disease
title_fullStr The Estrogen Receptor-β Expression in De Quervain’s Disease
title_full_unstemmed The Estrogen Receptor-β Expression in De Quervain’s Disease
title_short The Estrogen Receptor-β Expression in De Quervain’s Disease
title_sort estrogen receptor-β expression in de quervain’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661827/
https://www.ncbi.nlm.nih.gov/pubmed/26556342
http://dx.doi.org/10.3390/ijms161125968
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