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The Estrogen Receptor-β Expression in De Quervain’s Disease
Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661827/ https://www.ncbi.nlm.nih.gov/pubmed/26556342 http://dx.doi.org/10.3390/ijms161125968 |
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author | Shen, Po-Chuan Wang, Ping-Hui Wu, Po-Ting Wu, Kuo-Chen Hsieh, Jeng-Long Jou, I-Ming |
author_facet | Shen, Po-Chuan Wang, Ping-Hui Wu, Po-Ting Wu, Kuo-Chen Hsieh, Jeng-Long Jou, I-Ming |
author_sort | Shen, Po-Chuan |
collection | PubMed |
description | Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain’s. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand’s factor (vWF). De Quervain’s occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors—IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain’s disease is. ER-β might be a useful target for novel de Quervain’s disease therapy. |
format | Online Article Text |
id | pubmed-4661827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46618272015-12-10 The Estrogen Receptor-β Expression in De Quervain’s Disease Shen, Po-Chuan Wang, Ping-Hui Wu, Po-Ting Wu, Kuo-Chen Hsieh, Jeng-Long Jou, I-Ming Int J Mol Sci Article Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain’s. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand’s factor (vWF). De Quervain’s occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors—IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain’s disease is. ER-β might be a useful target for novel de Quervain’s disease therapy. MDPI 2015-11-04 /pmc/articles/PMC4661827/ /pubmed/26556342 http://dx.doi.org/10.3390/ijms161125968 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shen, Po-Chuan Wang, Ping-Hui Wu, Po-Ting Wu, Kuo-Chen Hsieh, Jeng-Long Jou, I-Ming The Estrogen Receptor-β Expression in De Quervain’s Disease |
title | The Estrogen Receptor-β Expression in De Quervain’s Disease |
title_full | The Estrogen Receptor-β Expression in De Quervain’s Disease |
title_fullStr | The Estrogen Receptor-β Expression in De Quervain’s Disease |
title_full_unstemmed | The Estrogen Receptor-β Expression in De Quervain’s Disease |
title_short | The Estrogen Receptor-β Expression in De Quervain’s Disease |
title_sort | estrogen receptor-β expression in de quervain’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661827/ https://www.ncbi.nlm.nih.gov/pubmed/26556342 http://dx.doi.org/10.3390/ijms161125968 |
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