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Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region
The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during nor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661829/ https://www.ncbi.nlm.nih.gov/pubmed/26556349 http://dx.doi.org/10.3390/ijms161125970 |
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author | Sureda-Gómez, Miquel Pascual-Carreras, Eudald Adell, Teresa |
author_facet | Sureda-Gómez, Miquel Pascual-Carreras, Eudald Adell, Teresa |
author_sort | Sureda-Gómez, Miquel |
collection | PubMed |
description | The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during normal homeostasis. Accordingly, four wnts (posterior wnts) are expressed in a nested manner in central and posterior regions of planarians. We have analyzed the specific role of each posterior wnt and the possible cooperation between them in specifying and patterning planarian central and posterior regions. We show that each posterior wnt exerts a distinct role during re-specification and maintenance of the central and posterior planarian regions, and that the integration of the different wnt signals (βcatenin dependent and independent) underlies the patterning of the AP axis from the central region to the tip of the tail. Based on these findings and data from the literature, we propose a model for patterning the planarian AP axis. |
format | Online Article Text |
id | pubmed-4661829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46618292015-12-10 Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region Sureda-Gómez, Miquel Pascual-Carreras, Eudald Adell, Teresa Int J Mol Sci Article The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during normal homeostasis. Accordingly, four wnts (posterior wnts) are expressed in a nested manner in central and posterior regions of planarians. We have analyzed the specific role of each posterior wnt and the possible cooperation between them in specifying and patterning planarian central and posterior regions. We show that each posterior wnt exerts a distinct role during re-specification and maintenance of the central and posterior planarian regions, and that the integration of the different wnt signals (βcatenin dependent and independent) underlies the patterning of the AP axis from the central region to the tip of the tail. Based on these findings and data from the literature, we propose a model for patterning the planarian AP axis. MDPI 2015-11-05 /pmc/articles/PMC4661829/ /pubmed/26556349 http://dx.doi.org/10.3390/ijms161125970 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sureda-Gómez, Miquel Pascual-Carreras, Eudald Adell, Teresa Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region |
title | Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region |
title_full | Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region |
title_fullStr | Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region |
title_full_unstemmed | Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region |
title_short | Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region |
title_sort | posterior wnts have distinct roles in specification and patterning of the planarian posterior region |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661829/ https://www.ncbi.nlm.nih.gov/pubmed/26556349 http://dx.doi.org/10.3390/ijms161125970 |
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