Cargando…

Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation

Osteolytic bone diseases are commonly presented with enhanced osteoclast formation and bone resorption. Sesquiterpene lactone natural compounds have been found to possess anti-inflammatory and immune-modulation effects. Here, we identified three germacrane sesquiterpenes using computer-based virtual...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Shengnan, Ang, Estabelle, Dai, Libing, Yang, Xiaohong, Ye, Dongping, Chen, Honghui, Zhou, Lin, Yang, Mingli, Teguh, Dian, Tan, Renxiang, Xu, Jun, Tickner, Jennifer, Pavlos, Nathan J., Xu, Jiake
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661831/ https://www.ncbi.nlm.nih.gov/pubmed/26556352 http://dx.doi.org/10.3390/ijms161125972

Ejemplares similares

Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-κB and NFAT Pathways
por: Zhou, Lin, et al.
Publicado: (2015)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption
por: Zhu, Sipin, et al.
Publicado: (2016)

Bajijiasu Abrogates Osteoclast Differentiation via the Suppression of RANKL Signaling Pathways through NF-κB and NFAT
por: Hong, Guoju, et al.
Publicado: (2017)

Amyloid β Peptide Enhances RANKL-Induced Osteoclast Activation through NF-κB, ERK, and Calcium Oscillation Signaling
por: Li, Shangfu, et al.
Publicado: (2016)

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
por: Zhou, Lin, et al.
Publicado: (2020)

Germacrane Sesquiterpene Dilactones from Mikania micrantha and Their Antibacterial and Cytotoxic Activity
por: Dong, Li-Mei, et al.
Publicado: (2023)

Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha
por: Zhang, Xin, et al.
Publicado: (2022)

Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts
por: Yan, Liuliu, et al.
Publicado: (2019)

Loss of Protein Kinase C-δ Protects against LPS-Induced Osteolysis Owing to an Intrinsic Defect in Osteoclastic Bone Resorption
por: Khor, Ee Cheng, et al.
Publicado: (2013)

PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast–osteoblast uncoupling
por: Li, Shangfu, et al.
Publicado: (2020)

M-CSF Potently Augments RANKL-Induced Resorption Activation in Mature Human Osteoclasts
por: Hodge, Jason M., et al.
Publicado: (2011)

Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways
por: Hong, Guoju, et al.
Publicado: (2020)

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
por: McDonald, Michelle M., et al.
Publicado: (2021)

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
por: McDonald, Michelle M., et al.
Publicado: (2021)

Three New Germacrane-Type Sesquiterpenes with NGF-Potentiating Activity from Valeriana officinalis var. latiofolia
por: Chen, Heng-Wen, et al.
Publicado: (2013)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
por: He, Jianbo, et al.
Publicado: (2021)

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption
por: Jang, Jin Sun, et al.
Publicado: (2019)

ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts
por: Liang, Xinyue, et al.
Publicado: (2021)

ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption
por: Qiu, Heng, et al.
Publicado: (2023)

Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts
por: Takegahara, Noriko, et al.
Publicado: (2016)

Palmitoleic Acid Inhibits RANKL-Induced Osteoclastogenesis and Bone Resorption by Suppressing NF-κB and MAPK Signalling Pathways
por: van Heerden, Bernadette, et al.
Publicado: (2017)

Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)
por: Zakłos-Szyda, Małgorzata, et al.
Publicado: (2020)

Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption
por: Lim, Soomin, et al.
Publicado: (2023)

DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling
por: Kaifu, Tomonori, et al.
Publicado: (2023)

NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-κB and Reactive Oxygen Species Pathways
por: Kim, Jung Ha, et al.
Publicado: (2015)

FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression
por: Lv, Zheng-tao, et al.
Publicado: (2018)

Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation
por: Wu, Lili, et al.
Publicado: (2019)

IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
por: Kim, Inyoung, et al.
Publicado: (2021)

Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation
por: Kong, Xiangying, et al.
Publicado: (2015)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways
por: Yuan, Yu, et al.
Publicado: (2020)

Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways
por: Sun, Kaiqiang, et al.
Publicado: (2022)

Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling
por: Xue, Chunchun, et al.
Publicado: (2023)

Correction to: Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation
por: Kong, Xiangying, et al.
Publicado: (2021)

TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function
por: Wu, Mengrui, et al.
Publicado: (2012)

RO4929097 regulates RANKL-induced osteoclast formation and LPS-mediated bone resorption
por: Huang, Tao, et al.
Publicado: (2021)

Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL-mediated NF-κB and JNK and their downstream signalling pathways
por: Huang, Xiao-Lin, et al.
Publicado: (2022)

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα–NF-κB p65 Complex
por: Chen, Junchun, et al.
Publicado: (2022)

Asperpyrone A attenuates RANKL‐induced osteoclast formation through inhibiting NFATc1, Ca(2+) signalling and oxidative stress
por: Chen, Xi, et al.
Publicado: (2019)

(+)/(−)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors
por: Xia, Gui-yang, et al.
Publicado: (2017)

Germacranes and m-Menthane from Illicium lanceolatum
por: Zhao, Ming, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gb9b2seu44ms992jbdqpg6m5os