Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The...

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Detalles Bibliográficos
Autores principales: Li, Wan-Fei, Wang, Juan, Zhang, Jing-Jie, Song, Xun, Ku, Chuen-Fai, Zou, Juan, Li, Ji-Xin, Rong, Li-Jun, Pan, Lu-Tai, Zhang, Hong-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661929/
https://www.ncbi.nlm.nih.gov/pubmed/26610490
http://dx.doi.org/10.3390/ijms161126071
Descripción
Sumario:Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC(50) value of 9.1 µM (SI = 12.2).

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