The kin17 Protein in Murine Melanoma Cells

kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line...

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Detalles Bibliográficos
Autores principales: Ramos, Anelise C., Gaspar, Vanessa P., Kelmer, Sabrina M. G., Sellani, Tarciso A., Batista, Ana G. U., De Lima Neto, Quirino A., Rodrigues, Elaine G., Fernandez, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661930/
https://www.ncbi.nlm.nih.gov/pubmed/26610484
http://dx.doi.org/10.3390/ijms161126072
Descripción
Sumario:kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line B16F10-Nex2 and in two derived subclones with different metastatic potential, B16-8HR and B16-10CR. Nuclear and chromatin-associated protein fractions were analyzed, and kin17 was detected in all fractions, with an elevated concentration observed in the chromatin-associated fraction of the clone with low metastatic potential, suggesting that the kin17 expression level could be a marker of melanoma.

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