Tuning the Phosphoryl Donor Specificity of Dihydroxyacetone Kinase from ATP to Inorganic Polyphosphate. An Insight from Computational Studies

Dihydroxyacetone (DHA) kinase from Citrobacter freundii provides an easy entry for the preparation of DHA phosphate; a very important C3 building block in nature. To modify the phosphoryl donor specificity of this enzyme from ATP to inorganic polyphosphate (poly-P); a directed evolution program has...

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Detalles Bibliográficos
Autores principales: Sánchez-Moreno, Israel, Bordes, Isabel, Castillo, Raquel, Ruiz-Pernía, José Javier, Moliner, Vicent, García-Junceda, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661931/
https://www.ncbi.nlm.nih.gov/pubmed/26610480
http://dx.doi.org/10.3390/ijms161126073

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