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Resources for the design of CRISPR gene editing experiments
CRISPR-based approaches have quickly become a favored method to perturb genes to uncover their functions. Here, we review the key considerations in the design of genome editing experiments, and survey the tools and resources currently available to assist users of this technology.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661947/ https://www.ncbi.nlm.nih.gov/pubmed/26612492 http://dx.doi.org/10.1186/s13059-015-0823-x |
| _version_ | 1782403082199498752 |
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| author | Graham, Daniel B. Root, David E. |
| author_facet | Graham, Daniel B. Root, David E. |
| author_sort | Graham, Daniel B. |
| collection | PubMed |
| description | CRISPR-based approaches have quickly become a favored method to perturb genes to uncover their functions. Here, we review the key considerations in the design of genome editing experiments, and survey the tools and resources currently available to assist users of this technology. |
| format | Online Article Text |
| id | pubmed-4661947 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46619472015-11-28 Resources for the design of CRISPR gene editing experiments Graham, Daniel B. Root, David E. Genome Biol Review CRISPR-based approaches have quickly become a favored method to perturb genes to uncover their functions. Here, we review the key considerations in the design of genome editing experiments, and survey the tools and resources currently available to assist users of this technology. BioMed Central 2015-11-27 2015 /pmc/articles/PMC4661947/ /pubmed/26612492 http://dx.doi.org/10.1186/s13059-015-0823-x Text en © Graham and Root. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Graham, Daniel B. Root, David E. Resources for the design of CRISPR gene editing experiments |
| title | Resources for the design of CRISPR gene editing experiments |
| title_full | Resources for the design of CRISPR gene editing experiments |
| title_fullStr | Resources for the design of CRISPR gene editing experiments |
| title_full_unstemmed | Resources for the design of CRISPR gene editing experiments |
| title_short | Resources for the design of CRISPR gene editing experiments |
| title_sort | resources for the design of crispr gene editing experiments |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661947/ https://www.ncbi.nlm.nih.gov/pubmed/26612492 http://dx.doi.org/10.1186/s13059-015-0823-x |
| work_keys_str_mv | AT grahamdanielb resourcesforthedesignofcrisprgeneeditingexperiments AT rootdavide resourcesforthedesignofcrisprgeneeditingexperiments |