Cargando…
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
INTRODUCTION: Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of innate immunity recognition systems including complement and the Toll-like receptor family initiate this disproportionate inflammatory response. The aim of this study was to explore the effect of com...
Autores principales: | Skjeflo, Espen W., Sagatun, Caroline, Dybwik, Knut, Aam, Sturla, Urving, Sven H., Nunn, Miles A., Fure, Hilde, Lau, Corinna, Brekke, Ole-Lars, Huber-Lang, Markus, Espevik, Terje, Barratt-Due, Andreas, Nielsen, Erik W., Mollnes, Tom E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662001/ https://www.ncbi.nlm.nih.gov/pubmed/26612199 http://dx.doi.org/10.1186/s13054-015-1129-9 |
Ejemplares similares
-
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
por: Hellerud, Bernt C., et al.
Publicado: (2017) -
CD14 and Complement Crosstalk and Largely Mediate the Transcriptional Response to Escherichia coli in Human Whole Blood as Revealed by DNA Microarray
por: Lau, Corinna, et al.
Publicado: (2015) -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
por: Lau, Corinna, et al.
Publicado: (2015) -
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets
por: Barratt-Due, Andreas, et al.
Publicado: (2017) -
Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs
por: Storm, Benjamin S., et al.
Publicado: (2022)