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Systems analysis of methylerythritol-phosphate pathway flux in E. coli: insights into the role of oxidative stress and the validity of lycopene as an isoprenoid reporter metabolite

BACKGROUND: High-throughput screening methods assume that the output measured is representative of changes in metabolic flux toward the desired product and is not affected by secondary phenotypes. However, metabolic engineering can result in unintended phenotypes that may go unnoticed in initial scr...

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Detalles Bibliográficos
Autores principales:	Bongers, Mareike, Chrysanthopoulos, Panagiotis K., Behrendorff, James B. Y. H., Hodson, Mark P., Vickers, Claudia E., Nielsen, Lars K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662018/ https://www.ncbi.nlm.nih.gov/pubmed/26610700 http://dx.doi.org/10.1186/s12934-015-0381-7

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