SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression

Adipocyte dysfunction correlates with the development of diabetes. Here we show that mice with a adipocyte-specific deletion of the SUMO-specific protease SENP1 gene develop symptoms of type-1 diabetes mellitus (T1DM), including hyperglycaemia and glucose intolerance with mild insulin resistance. Pe...

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Detalles Bibliográficos
Autores principales: Shao, Lan, Zhou, Huanjiao Jenny, Zhang, Haifeng, Qin, Lingfeng, Hwa, John, Yun, Zhong, Ji, Weidong, Min, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662081/
https://www.ncbi.nlm.nih.gov/pubmed/26596471
http://dx.doi.org/10.1038/ncomms9917

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