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Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma

PURPOSE: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma. METHODS: One-hundred-twenty-five patients with preperimetric primary open...

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Autores principales: Pahlitzsch, Milena, Torun, Necip, Erb, Carl, Bruenner, Jeanette, Maier, Anna Karina B, Gonnermann, Johannes, Bertelmann, Eckart, Klamann, Matthias K J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662372/
https://www.ncbi.nlm.nih.gov/pubmed/26640365
http://dx.doi.org/10.2147/OPTH.S93213
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author Pahlitzsch, Milena
Torun, Necip
Erb, Carl
Bruenner, Jeanette
Maier, Anna Karina B
Gonnermann, Johannes
Bertelmann, Eckart
Klamann, Matthias K J
author_facet Pahlitzsch, Milena
Torun, Necip
Erb, Carl
Bruenner, Jeanette
Maier, Anna Karina B
Gonnermann, Johannes
Bertelmann, Eckart
Klamann, Matthias K J
author_sort Pahlitzsch, Milena
collection PubMed
description PURPOSE: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma. METHODS: One-hundred-twenty-five patients with preperimetric primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (n=30) were included (mean age 58.9±15.9 years). All three devices graded the optic disc topography: Diagnosis 1 was defined as “outside normal limits”, while Diagnosis 2 as “borderline or outside normal limits”. RESULTS: For Diagnosis 1, a significant correlation was shown between DDLS and Moorfields regression analysis (P=0.022), and for Diagnosis 2 with glaucoma probability score analysis (P=0.024), in POAG. In pseudoexfoliation glaucoma, DDLS did not correlate significantly with Heidelberg Retina Tomograph 3 and optic coherence tomography. Regarding the area under the curve the highest predictive power was demonstrated by the objective DDLS (0.513–0.824) compared to Burk (0.239–0.343) and Mikelberg (0.093–0.270) coefficients. CONCLUSIONS: The DDLS showed a significant correlation to the Moorfields regression analysis in preperimetric POAG. The objective DDLS showed the highest predictive power and thus is an additive tool in diagnosing preperimetric glaucoma.
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spelling pubmed-46623722015-12-04 Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma Pahlitzsch, Milena Torun, Necip Erb, Carl Bruenner, Jeanette Maier, Anna Karina B Gonnermann, Johannes Bertelmann, Eckart Klamann, Matthias K J Clin Ophthalmol Original Research PURPOSE: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma. METHODS: One-hundred-twenty-five patients with preperimetric primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (n=30) were included (mean age 58.9±15.9 years). All three devices graded the optic disc topography: Diagnosis 1 was defined as “outside normal limits”, while Diagnosis 2 as “borderline or outside normal limits”. RESULTS: For Diagnosis 1, a significant correlation was shown between DDLS and Moorfields regression analysis (P=0.022), and for Diagnosis 2 with glaucoma probability score analysis (P=0.024), in POAG. In pseudoexfoliation glaucoma, DDLS did not correlate significantly with Heidelberg Retina Tomograph 3 and optic coherence tomography. Regarding the area under the curve the highest predictive power was demonstrated by the objective DDLS (0.513–0.824) compared to Burk (0.239–0.343) and Mikelberg (0.093–0.270) coefficients. CONCLUSIONS: The DDLS showed a significant correlation to the Moorfields regression analysis in preperimetric POAG. The objective DDLS showed the highest predictive power and thus is an additive tool in diagnosing preperimetric glaucoma. Dove Medical Press 2015-11-20 /pmc/articles/PMC4662372/ /pubmed/26640365 http://dx.doi.org/10.2147/OPTH.S93213 Text en © 2015 Pahlitzsch et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Pahlitzsch, Milena
Torun, Necip
Erb, Carl
Bruenner, Jeanette
Maier, Anna Karina B
Gonnermann, Johannes
Bertelmann, Eckart
Klamann, Matthias K J
Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_full Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_fullStr Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_full_unstemmed Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_short Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_sort significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662372/
https://www.ncbi.nlm.nih.gov/pubmed/26640365
http://dx.doi.org/10.2147/OPTH.S93213
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